Liquid Biopsy - Phase Scientific

PHASIFY™ is a novel sample preparation technology based on a proprietary liquid phase extraction mechanism. The technique achieves significantly greater yield of circulating cell-free DNA (cfDNA) compared to traditional solid phase methods such as spin columns and magnetic beads. Further, the PHASIFY™ platform provides modifiable, high-resolution size selection to enrich for target sizes of cfDNA.

In a head-to-head study at MD Anderson Cancer Center, PHASIFY™ demonstrated threefold greater cfDNA yield against traditional solid phase extraction, resulting in increased mutation detection in cancer patient plasma samples.

Novel Liquid Phase Extraction

Novel liquid phase extraction system.

Target cfDNA are purified and concentrated in one phase

Outstanding recovery and purity

BACK

Novel
liquid phase
extraction
system

Target cfDNA
are purified and
concentrated in
one phase

Outstanding
recovery and
purity

PHASIFY™ Advantage

High Yield: Multiple fold increase in cell-free DNA recovery compared to solid phase extraction, resulting in increased mutation detection and sensitivity

Size Selection: Modifiable and high-resolution size selection to enrich for target cfDNA (e.g., tumor DNA for oncology or circulating fetal DNA for NIPT)

High Concentration: Flexible elution volume as low as 5 µL, enabling high ﬁnal DNA concentration and maximizing DNA input for downstream diagnostics

Scalability: High sample input volumes without clogging and loss in throughput